CO2 lasers has a high absorption of water while low absorption of melanin and hemoglobin. It generates heat to coagulate content in water and produce epidermal ablation on targeted area accurately. With its wavelength in the mid-infrared at 10,600 nm, CO2 laser energy is well absorbed in water. As skin contains a very high water percentage, this makes the CO2 laser ideal for precise, safe ablation with good hemostasis. In addition to its efficacy in ablating benign raised lesions, the CO2 laser has been reported to be effective in the field of cutting, skin resurfacing, photo-rejuvenation as well as for intimate treatment. Nowdays Fractional CO2 laser is a necessary method for laser surgery.